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Pathophysiology of adrenals, testis and hair in X-ALD ABCD1 protein is present in the adrenal cortex but not in the adrenal medulla [32,33], while ABCD2 shows the opposite distribution [34]

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Additionally, Kong et al [41] showed that dietary factors metabolised by gut microbes can produce trimethylamine, which is transported to the liver and converted by hepatic flavin mono-oxygenase 3 (FMO3) into trimethylamine N -oxide (TMAO)

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