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These findings indicate that adding reduced glutathione to entecavir therapy could be a highly effective approach for managing chronic hepatitis B, particularly for improving liver function and accelerating viral clearance

Clinically, deficiency result in various pathologies, most notably, beriberi, a cardiomyopathy with edema and lactic acidosis, and WernickeKorsakoff syndrome or Wernickes encephalopathy

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The review protocol was registered on PROSPERO (Registration ID: CRD42025644894), ensuring methodological transparency and adherence to systematic review guidelines

Useful for comparing chemically plausible adducts with microsomal or hepatocyte findings

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