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(Liu is on scientific advisory board of the University of Oxfords Jenner Institute, which developed AstraZenecas vaccine for COVID-19.) Had this to say in The Scientist

We are aware that some of the subjects may have had genetically low concentrations of transcobalamin I (TCI), which is now known to be a benign condition that most probably does not need medical treatment [17]

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This two-needle method is a key step for comfort because it ensures the needle entering your skin is perfectly sharp and hasnt been dulled by piercing the vials rubber stopper

Medications that reduce B12 absorption: Proton pump inhibitors (PPIs) such as omeprazole, lansoprazole, and esomeprazole are amongst the most commonly prescribed drugs in elderly populations

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