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Research interest extends to nitric oxide system modulation, neuroprotection, and dopaminergic / serotonergic pathway interactions

Neuroimmune communication via calcitonin gene-related peptide (CGRP) and its coreceptor RAMP1 promotes macrophage recruitment and phenotypic shifts toward a pro-endometriosis state, characterized by impaired efferocytosis and enhanced support of endometrial cell growth ( Natural killer (NK) cell function is severely compromised, with reduced cytotoxicity of the CD56dimCD16+ subset in peripheral blood and peritoneal fluid, enabling immune escape of ectopic cells ( T-cell subsets are dysregulated, with increased Th2, Th17, and regulatory T (Treg) cells in the peritoneal microenvironment ( 2.2.2 Immune checkpoint molecules Immune checkpoint pathways are perturbed, contributing to immunosuppression

Promotion of VEGF (Vascular Endothelial Growth Factor) expression, supporting angiogenesis and vascular formation

Because the brain relies heavily on chemical signaling between neurons, peptides that affect these pathways are being investigated for cognitive support

Hepatocytes: a key cell type for innate immunity

In addition, it has been shown that necroptosis-inducing drugs could impact the effectiveness of ICIs in individuals with cancer (Tang et al., 2020)