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Wright GD d-Ala-d-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB

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at the beginning of the trajectory there were 93 contacts which increased to an average of 125(4) contacts in the last 50 ns, with almost 30 contacts formed by residues 8-11 (ring B) and 21-28 (ring D), see Figure 1