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172 Rodent 173 and human studies 174 reveal that leptin also modulates glucose and lipid metabolism through a brainvagusliver axis and hypothalamicpituitaryadrenal signaling, contributing to adverse communication among adipose tissue, the hypothalamus, the liver and the pancreas, exacerbating T2D

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It is secreted by the hepatic cells through fenestrated sinusoidal epithelium in to the space of Disse and enters the blood stream

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