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In addition, we investigated correlations between the levels of altered lipids and dopamine transporter (DAT) binding of MPTP-lesioned animals, LID behavioural scores of L-DOPA-treated animals and dopamine and L-DOPA levels within specific brain regions

The BBB in Parkinson's disease The pathophysiology of Parkinson's disease involves various potential pathways that can progressively worsen over time, leading to symptoms such as body tremors, muscle stiffness, unsteady gait, and difficulties with physical balance and coordination[45] (Fig

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In patients with SURF-1 mutations, symmetrical involvement of the bilateral brainstem and subthalamic nuclei is common, and some patients exhibit basal ganglia abnormalities