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However, a Phase I clinical involving monotherapy with 24-h intravenous PX-12 for treating advanced gastrointestinal cancer, while completed, showed no clinical activity but exhibited an atypical toxicity profile [229]

44 , 30s32s (2003)

Additionally, HCQ and CQ can bind to nucleic acids within the endosome, preventing the interaction of endosomal TLRs with their ligands and thereby inhibiting subsequent TLR activation

Immunology 148 , 92101 (2016)

The mechanism profile makes biological sense, the safety record appears favorable, and the practical results align with what the science would predict