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this reduces the enzymatic activity of MTHFR by approximately 35% per T allele , resulting in inefficient production of methylfolate ( Figures 3 and 4)

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Herein, we identified the excellent pharmacodynamic activity, multi-target characteristics and anti-tumor effect of the compound 1D228 as a new c-Met and TRK inhibitor candidate, which significantly suppressed tumor growth in c-Met and TRKB double expression tumors

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