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As MOTS-c activates AMPK and NRF2, it also indirectly suppresses the mTOR (mechanistic target of rapamycin) pathway, the master growth and anabolism regulator that, when chronically overactivated, accelerates the accumulation of senescent cells

The image of the left ventricular cavity was obtained from a long parasternal view, and the M mode cursor was positioned between the papillary muscles, just below the mitral valve plane