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Curcumin is a polyphenol from the rhizome of Curcumin longa L

Rheumatology (Oxford) 60(Suppl 6):vi53vi61

Nature 447:941950 Davies MJ (2005) The oxidative environment and protein damage

Microglial activation generates reactive oxygen species and damages the dendritic spines, destroying the synaptic connections between neurons and causing cognitive decline
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Gut microbial metabolism of L-carnitine, leading to the production of trimethylamine N-oxide (TMAO), links red meat consumption to cardiovascular risks

More recently, an umbrella review of 11 meta-analyses revealed that berberine significantly affects factors like blood glucose levels, insulin resistance and body composition as compared to controls
