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Invasive methods that primarily rely on disruption of the BBB integrity by osmotic or biochemical means, or direct intracranial drug delivery by intracerebroventricular, intracerebral or intrathecal administration after creating reversible openings in the head are recognized [54]

However, PGE2 is known to play a dual role, as it can both suppress the immune response against M.tb and protect the host from excessive inflammation, suggesting that NSAIDs should be exercised with caution for TB treatment [128]

Gagrani, A., Ding, B., Wang, Y

New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues

Expert Opinion on Biological Therapy