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Preclinical studies have shown that cobalamin inhibits glutamate exocytosis, as an excitatory pain neurotransmitter, and when infused intracerebroventricularly, increases GABA cell contents, as an inhibitory pain neurotransmitter [6, 9]

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Gene therapies to upregulate specific isoforms and biomarkers for early detection are also on the horizon, aiming for personalized interventions

Abstract Curcumin, a natural polyphenol derived from Curcuma longa , exhibits potent multimodal anticancer activity by modulating critical oncogenic pathways (e.g., NF-B, STAT3, PI3K/Akt/mTOR), inducing apoptosis, suppressing angiogenesis, and reversing multidrug resistance (MDR)

All ligation reactions were performed using Ligation high Ver

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