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The overload of iron ions exacerbates the occurrence of cerebral hemorrhage, inducing the onset of ferroptosis (11)

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The BPI, originally developed for assessing cancer pain, uses numeric rating scales to evaluate both pain severity and its impact on daily function and helps identify patterns suggestive of somatic or visceral nociception such as localized aching or pressuresensitive pain exacerbated by the movement

All these molecular modulations induced by curcumin with vital health benefits could be exploited in alternative therapeutics to manage severe diseases in humans (Figure 2)

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