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Although we only detected a mild alteration of autophagy in the L166P lines, -syn oligomers were formed due to impaired lysosomal degradation of -syn

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Melatonin stabilizes mitochondria, enhances Nrf2-driven antioxidant defenses, and restrains NF-B activity

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Alzheimers disease is characterized by the extracellular accumulation of amyloid- (A) that the insertion of A into membrane will generate hydroperoxides, lipid peroxides and neurogenerative products (e.g., MDA) via Fenton reaction [235,236,237]

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Because adenosine/ATP has an impact on energy metabolism, cardiovascular functions and blood flow, it is taken as an over-the-counter oral supplement to boost endurance and athletic performance, although theres mixed evidence regarding its effectiveness

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The following primers were used: mFIAF-PPRE (forward primer 5-GGCAGACCCAGAAAGATGG-3, reverse primer 5-CCGATTGGATGAGAGGAAAG-3) mADRP-PPRE (forward primer 5-GCTGGGGATTACAGACCAGA-3, reverse primer 5-TCTTGGGGTTTTGGAAAATG-3) Transactivation assays COS-7 cells were cultured in 12-well plates and co-transfected with PPRE X3-TK-luc, pRL-TK, pXJ40-3xFlag-FABP5 WT, or C127S, according to the Lipofectamine reagent protocol (Invitrogen, 11668-019)

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Targeting HIF-1 for cancer therapy

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