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Total and LDL cholesterol levels increased in the L-carnitine group, and L-carnitine supplementation was also associated with 9.3% greater carotid arterial plaque stenosis in males who ate less red meat and had lower baseline stenosis and total plaque volume than other participants.26 A 2018 study including participants on a nonvegetarian diet found that 24 weeks of supplementation with 1,500 mg of L-carnitine increased fasting blood levels of carnitine and increased levels of TMAO tenfold but did not increase lipids, inflammatory markers, or other markers of atherosclerosis in healthy, omnivore, nonsmoking, physically active women ages 65 to 70 when compared with placebo

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Fish, -3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women: the JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) study