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Fasting leads to reduced microbiome-derived propionate production Short-chain fatty acids (SCFAs), which include propionate, are products of gut microbiome

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[1] Excellent source of inhibitory amino acids that balance the overabundance of excitatory amino acids (tryptophan, cysteine, etc.) from muscle meats
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Nasca C, Rasgon N, McEwen B (2019) An emerging epigenetic framework of systemic and central mechanisms underlying stress-related disorders

As we age, mitochondrial function can decline, leading to reduced energy production and a metabolic slowdown
