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Reconstituted high-density lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of phosphatidylinositol 3-kinase but not Akt/endothelial nitric oxide synthase

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In fact, a meta-analysis of clinical trials found a modest benefit for individuals with mild cognitive impairment, though a separate systematic review concluded more evidence is needed before clinical recommendations can be made