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Lower age at radiation exposure is associated with a lower adult height SDS (227) with height loss from spinal irradiation estimated at 9 cm when exposed at 1 year, 7cm when exposed at 5 years and 5.5 cm when exposed at 10 years

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Gusarov I., Shamovsky I., Pani B., Gautier L., Eremina S., Katkova-Zhukotskaya O., Mironov A., Makarov A., Nudler E

426 When cancer cells are subjected to different therapeutic pressures such as chemotherapeutic drugs, targeted agents, ionizing radiation, and monoclonal antibodies, they can gradually evolve different mechanisms of resistance

This was probably because DOXHCl was water soluble and could be transported into cells quickly by a passive-diffusion mechanism, whereas the drug-loaded micelles were internalized via endocytosis effect, which delayed the drug release of DOX in the micelles