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Tumors simultaneously rewire antioxidantsactivating NRF2 and elevating GSH/thioredoxin systemscreating a narrow therapeutic window in which pushing ROS beyond buffering capacity triggers apoptosis or ferroptosis, whereas indiscriminate scavenging blunts therapy and fosters resistance (Reczek and Chandel 2017)

Glutathione is involved in tissue building and repair, making chemicals and proteins needed in the body, and in immune system function

4 Rasburicase rapidly reduces hyperuricemia by converting nephrotoxic uric acid into allantoin, which is more easily and safely cleared by the kidneys

doi: 10.1016/j.cmet.2015.08.024

We assumed that alleviation of hyperthyroidism by PTU administration would affect AChE and DA levels

The degree of suppression depends on factors such as the testosterone formulation, the dose, the duration of use, and individual genetic variation in hormone metabolism