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In humans, local axonal disturbance leading to myokymia may be caused by demyelination (multiple sclerosis, Guillain-Barr syndrome, chronic inflammatory demyelinating polyneuropathy, radiation plexopathy), edema (pontine tumors), toxins (rattlesnake envenomation and clozapine administration), and ischemia, but not usually by nerve compression without the above changes

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Moreover, isatuximab exhibits immunomodulatory effects by blocking the suppressive function of Tregs, consequently fostering NK- and T-cell-mediated antitumor immune responses [83]

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