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Second, while our enzymatic assays suggest direct inhibition of G6PD by caffeine, these findings require further validation in vivo , particularly in G6PD-deficient individuals, in whom an exacerbated hemolytic phenotype was not observed

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Lysosomal accumulation was observed in SMCR8 deficient macrophages from Smcr8 /mice , possibly because of increased ROS (Mcalpine et al., 2018)

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