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For example, C247 of rhodanese is located at the intersection of the axes of two helices, which contribute a significant electrical field and lower the p K a of the thiol group (estimated to be 6.5) by 3.5 units, making this sulfur atom very nucleophilic

Such results have encouraged the formulation and application of Phase III studies, which will initially focus on combinations of TLK286 and taxotere in the treatment of drug-resistant NSCLC

In this context, inflammatory cytokines and immune cell secretions function as a regulatory valve. In addition to NF-KB and Nrf2/HO-1, the NLRP3 inflammasome and cGAS-STING pathways also play distinctive roles in ferroptosisinflammation crosstalk

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Oven et al., 2001)

(2023) 103(1_suppl):153S161S