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The effects of RPM on the transcriptome profile during follicular and early embryo were investigated, and the results showed that it is likely that DNA methylation may have been a mechanism utilized to modulate gene expression patterns (Peagaricano et al., 2013)

Gene therapy using CRISPR-Cas9 and AAV-mediated wild-type OPA1 expression is in preclinical development [178], with CRISPR-based gene editing proven successful in vitro for the OPA1 missense mutation [179]

Sanders and Griffin, 2016)

In contrast, GPER1 is a membrane-associated G protein-coupled receptor that operates in a distinct manner

doi: 10.3390/antiox12030695 27 HashimotoOMooreRKShimasakiS

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