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The related modulatory mechanisms namely regulating Hadhb-mediated FAO, the Sirt1/NF-kB signaling pathway, and mTORC2/PPAR-g signaling and other pathways are involved [72, 73]
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Notably, a premature shift of neural stem cells away from neuronogenesis and to gliogenesis seems to play a leading role in several syndromes
Microbiol Spectr 4 Lu YC, Sanada C, Xavier-Ferrucio J, Wang L, Zhang PX, Grimes HL, Venkatasubramanian M, Chetal K, Aronow B, Salomonis N, Krause DS (2018) The molecular signature of megakaryocyte-erythroid progenitors reveals a role for the cell cycle in fate specification
Thus, impaired oxidative metabolism results in decreased energy production, increased cortical excitability, and CSD, which in turn causes migraines when mitochondrial damage or dysfunction occurs in the brain
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