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doi: 10.1210/clinem/dgac733

The formation of adducts between these carcinogenic metabolites and DNA in bladder epithelial cells can lead to gene mutations and cellular transformations, significant mechanisms in the development of bladder cancer ( Figure 2 )

A.WestonT

10.2131/jts.10.29 124 LangstonJ

This is achieved by stimulating the activity of immune cells, such as M1 macrophages and CD8+ T lymphocytes, and by promoting the secretion of pro-inflammatory cytokines, including interferon-gamma

Furthermore, close BPC 157/NO-system relations with the gasotransmitters crossing the cell membrane and acting directly on molecules inside the cell may envisage particular interactions with receptors on the plasma membrane of their target cells