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34 , 874887.e876 (2022)

In conclusion, the present review summarized the role of ferroptosis in the pathology of AD and how mechanisms such as iron metabolism disorders, lipid peroxidation and GSH depletion lead to neuronal damage, as well as the role of ferroptosis inhibitors such as vitamin E, Se and Fer-1 as potential therapeutic strategies

Greineder et al., Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain

10.1016/0006-2952(91)90531-9 235 StiffA.TrikhaP.Mundy-BosseB.McmichaelE.MaceT

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This can be observed in the modulation of BCL2 family protein levels by ROS, as heightened pro-apoptotic BAX and BAK1 levels accompanied by a decrease in anti-apoptotic BCL2 and BCL2-like 1 (BCL2L1/BCL-XL) expression are observed in squamous cell carcinoma cells [114]
