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PMCID: PMC5112015

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Bacterial cells, such as lipopolysaccharides (LPS) and peripheral inflammatory mediators enter the brain via BBB, causing neural inflammation, and subsequently induce neuropathological changes, such as synaptic defects, degeneration, abnormal neurons, and brain chemicals discharge which contribute to the development of depressive disorders

This is also where you need to pay attention to appetite suppression patterns

Mood changes, including depression or irritability, can also be related to low B12 levels

Neurological symptoms may start improving within 12 weeks, but longstanding complications can require 36 months of treatment, with some damage potentially irreversible