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Obesity drug pipeline: developing therapies for a complex disease

Light, heat, and oxygen are their enemies

"The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Diet-Induced Obesity." Cell Metabolism

Certain people are at greater risk for deficiency because of things like diet, lifestyle, and prescription medications

High prevalence of cobalamin deficiency in elderly outpatients

Hong S, Moreno-Navarrete JM, Wei X, Kikukawa Y, Tzameli I, Prasad D, Lee Y, Asara JM, Fernandez-Real JM, Maratos-Flier E, Pissios P. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94. doi: 10.1038/nm.3882. Epub 2015 Jul 13. PMID: 26168293; PMCID: PMC4529375