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Thus, the use of topical and systemic JAK inhibitors (tofacitinib, ruxolitinib, and baricitinib) is currently under intense clinical investigation (phase 2 and phase 3 trials) [97]
doi: 10.1046/j.1523-1747.2002.19602.x
O.WoodJ
Pharmacopsychiatry 2001 Jul
Locally advanced disease with invasion to the adjacent tissue or vasculature is common
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