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MC4R-expressing neurons in the paraventricular nucleus project to brainstem autonomic centers and interface with dopaminergic pathways in the medial preoptic area, a region critical for sexual motivation and arousal

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Biologists have proposed mechanisms by which this could occur that fall into two broad categories

For a diagnosis of NF1 to be made, at least two of the following symptoms should be present: Six or more CALMs, with a size greater than 5mm in children or over 15mm in adults At least one plexiform neurofibroma, which is a type of benign tumor, or any two other types of neurofibromas Freckles in the armpit or groin area, a sign indicative of NF1 Optic glioma, a type of brain tumor affecting the eyes Two or more Lisch nodules, which are benign growths on the iris of the eye A distinct bone abnormality, like abnormal bone thinning or a condition causing false joints in the bone A first-degree relative, such as a parent, sibling or child, with a diagnosis of NF1 There are other genetic syndromes associated with multiple CALMs, including Neurofibromatosis type 2 (NF2), McCune Albright Syndrome, Legius syndrome, Watson Syndrome, and Noonan syndrome with multiple lentigines (also known as LEOPARD syndrome)

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