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Research suggests it influences several overlapping biological systems simultaneously, which may explain why it shows up across such a wide range of tissue types in preclinical studies

10.3389/fimmu.2025.1534926 122 ZhaoY.ChenZ.XieS.XiaoF.HuQ.JuZ

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Matrix metalloproteinases (MMPs) are up-regulated by pro-inflammatory cytokines, as well as by acute phase proteins like serum amyloid A (SAA), with counter-regulatory inhibition by IL-4 and IL-13, and released into the circulation from damaged vascular endothelium

Despite our bodies' ability to produce glutathione, various factors such as aging, poor diet, environmental toxins, and chronic stress can deplete its levels

The pooled prevalence of depressive symptoms in osteoarthritis was 19.9% (95%CI: 14.823.5%, n = 9,811), while the corresponding prevalence for anxiety symptoms was 20.8% (95%CI: 15.127.9%