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Additionally, cysteine serves as an alternative pyruvate source for cancer cells, with its breakdown providing approximately 20% of cellular pyruvate [53]

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Notably, we found that glycerol induced a significant upregulation of the gene cluster saci_2031-2034 (Fig

This study complies with relevant institutional, national, and international guidelines and legislation

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However, some non-mechanotransduction channel blockers, such as N-acetylcysteine [23, 63] and salicylates [64, 65], provide ear protection by enhancing the production of endogenous antioxidants without affecting the antitumor activity of cisplatin, which is an advantage of non-MET channel-blocking ear protection drugs