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Yes, though it is rare

doi: 10.1186/1471-2091-11-3

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#Pharmacology #NSAIDs #ClinicalPharmacy #PharmaceuticalScience #DrugMechanism #PharmacyStudents #MedicalEducation To view or add a comment, sign in Medical Alert: A Dangerous Drug Combination That Could Trigger Seizures A new study has found that combining Tramadol, a commonly prescribed painkiller, with certain antidepressants (such as Fluoxetine, Paroxetine, Sertraline, and Bupropion) can significantly increase the risk of seizures, especially in older adults

doi: 10.1038/mp.2014.163 76 Ben-SkowronekISzewczykLKulik-RechbergerBKorobowiczE

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