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Fan S, Smith ML, Rivet DJ, Duba D, Zhan Q, Kohn KW, Fornace Jr AJ and O'Connor PM

We used the following descriptors and their combinations in our research: intestinal/gut barrier/permeability, leaky gut/intestine, zonulin, gut dysbiosis, disease, cause, diagnosis, treatment, therapy, physical activity, exercises

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Inhibitors targeting glutamine metabolism have demonstrated significant antitumor potential by impeding energy supply, inducing oxidative stress, and activating immune response

Further research is essential to establish standardized protocols for their use and to ensure their integration into clinical practice as effective therapeutic options