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Changs recommendations

Dominguez LJ et al

Themido, R., Loureiro, M., Pecegueiro, M., Brandao, M

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Optimal use cases for Botox-only approach include severe expression wrinkles unresponsive to topical interventions , users prioritizing maximum results over cost/naturalness, very deep frown lines creating angry appearance affecting professional interactions, specific aesthetic goals (completely smooth forehead) requiring paralysis, and users comfortable with injections, quarterly commitment, and higher expense accepting trade-offs for superior effectiveness as detailed in professional treatment guides

Astrocyte activation can lead to the release of trophic factors such neurotrophin-3 (NT-3), glial cell line-derived neurotrophic factor (GDNF) and BDNF (Juri et al., 2011