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Moller, S

These data suggest that ALA derivatives hold promise for treating a variety of diseases, from neurodegenerative disorders to cardiovascular diseases and cancers

doi: 10.3389/fcell.2026.1672284 Received 24 July 2025 Revised 28 December 2025 Accepted 05 January 2026 Published 30 January 2026 Volume 14 - 2026 Edited by Liqing Zang, Mie University, Japan Reviewed by Sergey Yaklichkin, Memorial Sloan Kettering Cancer Center, United States Lian Chun Tang, Wuchang Hospital, China Xiangwen Shi, Kunming Medical University, China Updates Copyright 2026 Li, Yang, Deng, Yu, Huang, Yang, Yang, Zhang and Xiong

Signer, R

MEHP can induce tumorigenesis through activation of the nuclear transcription factor peroxisome proliferator-activated receptor-alpha (PPAR), a ligand-activated transcription factor belonging to the nuclear receptor superfamily and able to bind the retinoid X receptor to activate the transcription of selected genes [147]