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doi: 10.1155/2021/6631805

(2018) reported that removal of these cells in INK-ATTAC transgenic mice prevents gliosis, reduced tau hyperphosphorylation in both soluble and insoluble forms, impeded neurofibrillary tangle formation, and prevented cortical and hippocampal neurodegeneration, thus preserving cognitive function

Deep: reaches the deeper layers of the skin, used for deep wrinkles and older scars

This upregulation results in a substantial accumulation of intracellular Fe2+, causing tissue damage (127)

Subgroup analyses and meta-regressions are warranted in future work to explore these moderators

PMID: 30074168