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2.1.5 IL-22 Several studies have shown that the expression of the Th22 cell cytokine IL-22 is elevated in pruritic PN lesions, which is potentially associated with impaired epidermal proliferation and differentiation and skin inflammation (27, 51)

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Pain relief To find relief from injection site soreness, try the following: Keep your arm moving and use it throughout the day Place a clean, cool, wet washcloth over the area Take a pain-relieving medication such as ibuprofen, acetaminophen or aspirin (but only consider this after you get the vaccine, not before) Seek medical attention if Patients will want to seek medical attention immediately if they experience any of the following: If the arm pain or tenderness starts to get significantly worse within 24 hours of getting the vaccine If the symptoms do not go away after several days, or if the patient sees a spreading rash down their arm While a sore arm for a day or two is not the most pleasant or fun experience, it is a sign that the vaccine you just received is doing what it is meant to do protecting you and those around you