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The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

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therefore, it must be obtained from diet or supplements

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In addition to the systemic side effect of the weakened immune system, there can also be some more localised side effects from steroid injections, such as atrophy or shrinkage or thinning of surrounding tissues

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