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Taken together, these results indicate that metabolic similarity networks provide a biologically grounded, node-centric organizational framework that is locally consistent with but globally distinct from the white matter edge-centric connectome

10.1016/j.pep.2008.08.011 Protein Expr

Therefore, UBB+1 is involved in both secretase-dependent and independent pathways for A generation and this could be a reasonable explanation as to why UBB+ conjugated protein aggregation has been found to be associated with A plaques in transgenic UBB+1 AD brain (van Leeuwen et al., 2006

10.1152/japplphysiol.00537.2004 71

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NaHS and GYY4137 reversed Hcy-induced ER stress in aortic plaques by reducing the expression of protein disulphide isomerase (PDI), a redox-dependent protein and a key enzyme of protein folding, in VSMCs and endothelial cells