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N -Methylation of Compounds 1.70 and 1.71 was achieved using the steps outlined in Figure 2 on resin using 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU)

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So that, this technology is expected to become more widespread because of their advantages against other methods as chemical, with public health effects ( Magbanua et al., 2006 ), or catalysis with long exposure periods for achieving reasonable results of inactivation

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doi: 10.1021/acs.jmedchem.1c01856