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Key Points Testosterone deficiency is highly prevalent in men with the metabolic syndrome and type 2 diabetes mellitus Low levels of testosterone are an independent risk factor that predicts subsequent development of the metabolic syndrome and type 2 diabetes mellitus Population studies in community-dwelling men have shown that testosterone deficiency is associated with increased all-cause mortality and cardiovascular mortality The hypogonadalobesityadipocytokine hypothesis summarises the complex interaction of the above components and their contribution to the vicious cycle of obesity causing hypogonadism and vice versa Interventional studies of testosterone replacement therapy have shown improvements in insulin resistance, body composition, glycaemic control, lipid metabolism and other cardiovascular risk factors The benefit of testosterone on insulin sensitivity might be attributable to a complex regulatory influence on insulin signalling and glucose homeostasis in the major insulin-responsive target tissues This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 183,71 per year only 15,31 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

10.1177/107424849900400203 J

241 Because of its central role in methylation, Met is considered a candidate target for tumor therapy driven by ten-eleven translocation (TET), isocitrate dehydrogenase (IDH) proteins, methyltransferases, and other phenotypic modifiers

Conoscenze attuali e prospettive future Oggigiorno si sa che la carnitina una molecola coinvolta nei processi mitocondriali che portano alla produzione di energia, indispensabile per lo svolgimento di tutte le attivit necessarie alla vita della cellula