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In this model of transient insomnia, a single 6 mg dose of doxepin given to healthy volunteers was well tolerated and resulted in significant improvements in PSG-defined and patient-reported sleep onset, maintenance, and duration endpoints that lasted into the last hour (hour 8) of the night

doi:10.1002/14651858.cd001157

Currently, SER-109 and REBYOTA have been approved by the FDA to prevent rCDI

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