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Anderson P, Saltin B: Maximal perfusion of skeletal muscle in man
Collectively, these novel therapeutic venues for the treatment of melanoma have improved overall survival
They do this by decreasing the activity of the protein breakdown pathway, and also by decreasing the expression of several complexes involved in protein breakdown
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While not investigated in the study, trastuzumab resistant cells could also harbor epigenetic modifications that further alter the metabolic profile of resistant cells
doi: 10.1016/j.clineuro.2005.10.012
