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In a 4-years randomized trial involving eyes with moderate to severe non-proliferative diabetic retinopathy (NPDR) without center-involved diabetic macular edema (CI-DME), prophylactic intravitreal aflibercept (anti-VEGF) significantly reduced progression to proliferative diabetic retinopathy (PDR) or CI-DME ( Emerging biology highlights the importance of identifying upstream targets that contribute to the pathogenesis of DR

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Standard growth factors like EGF, FGF, and VEGF dont match this range
