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Its expression and activity are altered in OA cartilage under pathological conditions, suggesting a crucial role for GPX4 in OA pathogenesis and treatment

Heat shock protein 27 downregulates the transferrin receptor 1-mediated iron uptake

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Lei P, Bai T, Sun Y (2019) Mechanisms of ferroptosis and relations with regulated cell death: a review

Under typical conditions, it is continually processed with the help of folate, vitamin B12, vitamin B6, and related nutrients

Previous studies support this hypothesis
