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POS has been proposed as a probable mechanism contributing to systemic OxS, T2D progression, and vascular damage (see Figure 3) [91,92]

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(2015) found that in skin keratinocytes at a concentration of 10 mM vitamin E, the enzyme activity of GST significantly decreased by 74% ( p 0.001)

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However, brains of GPx1 deficient mice have increased oxidative stress at baseline, and increased production of ROS in response to kainic acid

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