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In cardiomyocytes, NO plays a key regulatory role in intracellular calcium handling, mitochondrial respiration, and redox balance 38,39,40

Similarly, examining how acute and/or repeated applications of neuropeptides affect expression of mucins (e.g., muc5AC, muc5B) in asthma, COPD, and CF would reveal a potentially causative role for neuropeptides in airway mucus phenotypes

50 , 51 Ca 2+ -ATPase extrudes calcium, maintaining low intracellular levels of 5 to 10 mol/L

Proteins were separated via SDS-PAGE and then transferred to PVDF membrane (Millipore, Billerica, MA, USA)

Arachidonate-15-lipoxygenase and other iron-containing lipoxygenases (LOXs) catalyze the reaction between O 2 and polyunsaturated lipids, forming LOOH, with iron integral to the catalytic subunit of LOX