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Apoptotic pathways in LHON were extensively investigated and include a caspase-dependent pathway, via caspase-8/cleaved Bid/cyt c and activation of the apoptosome, formed by Apaf-1/cyt c /caspase-9, with final induction of caspase-3 [499,500]

These positive effects suggested the improvement in locomotor, memory and cognitive functions, which may be credited to the depicted abilities of the tested agents to reverse MSG-induced perturbation in glutamate levels, thereby hampering the resultant excitotoxic effects and opposing MSG-mediated alterations in neurotransmitters levels

This antioxidant-like activity makes DSIP a candidate of interest in ongoing experimental research, though further study is necessary to clarify the extent and mechanisms of these effects

Use raw or lightly cooked in meals, curries or salads to preserve glutathione and antioxidants

Comparison studies consistently show GHK-Cu outperforming other collagen-stimulating ingredients